The bioavailability of the drug when administered at 16% -18%. Maximum effect occurs within 6 hours. The total clearance of 1.2 ml / min, the elimination rate constant for single dose dimethyl nandrolone undecanoate 1000 . Since plasma protein and formed elements are not linked. The half-life of the drug by measuring the specific activity in blood was 12 minutes. Since plasma protein and formed elements are not linked. It does not accumulate in the body with the recommended dose and the multiplicity of reception. The main route of excretion of the drug through the kidneys (80%). Partially metabolized and excreted by the liver (20%).
Indications for use
as an adjunct in the treatment of chronic venous insufficiency.
Contraindications for use
- Hypersensitivity to the drug;
- age of 18 years (effectiveness and safety have been established);
- gastric ulcer and duodenal ulcer (in the acute stage);
- simultaneous with drugs containing salts of divalent metals (calcium, magnesium, zinc, iron) and tetracycline antibiotics (tetracycline, chlortetracycline hydrochloride, oxytetracycline hydrochloride and).
Dosage, method of administration
The drug is used inside for 30-40 minutes dimethyl nandrolone undecanoate 1000 before meals for 800-1600 IU per day, divided into two doses. The maximum daily dose – 2000 IU. The course of treatment 20 days. In the absence of efficiency throughout the course of treatment should consult a doctor. If necessary, you can repeat courses on doctor’s advice.
Precautions when taking
- polyvalent allergy;
- chronic obstructive pulmonary disease;
- the threat of bleeding esophageal varices;
- gastric ulcer and duodenal ulcer (in remission).
Overdose symptoms, relief measures in overdose
no cases of overdose.
Possible side effects
Allergic reactions, in rare cases, dyspeptic symptoms (nausea, vomiting, feeling of heaviness in the stomach). Perhaps a temporary feeling of fullness in the lower extremities.
Interactions with other drugs
heparin, dipyridamole, aspirin increases the antithrombotic effect without increasing the threat of bleeding. The use of antibiotic tetracycline (tetracycline hydrochloride and hlorgetratsiklina oksitetratsikliia hydrochloride) enhances fibrinolytic effect. If necessary, the use of drugs containing divalent metal salts (calcium, magnesium, zinc, iron) in connection with a possible decrease in the enzyme activity, it is desirable to comply with the interval between doses ® and these drugs for at least 40 minutes.
Capabilities and features of the application during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation.
Effects on ability to drive vehicles, machinery
studies have not been conducted on the dimethyl nandrolone undecanoate 1000 possible impact of the drug on the ability to drive vehicles, machinery, since the drug and its components do not apply to substances that can affect the psychomotor condition of the person.