Excessive doses can cause amplification of side effects, mainly nausea, vomiting, and vertigo; In more severe cases, there may be a ataxia, paresthesias, and seizures. Treatment is symptomatic. There dimethyl nandrolone undecanoate testosteroneis no specific antidote.In applying the metronidazole solution for infusion, interaction with other drugs slightly, however, caution should be exercised with concomitant administration of some drugs: Warfarin and other indirect anticoagulants. Metronidazole increases the effects of anticoagulants, which leads to increased formation of prothrombin time.
Concomitant use may lead to the development of a variety of neurological symptoms, therefore, should not be prescribed metronidazole patients who took disulfiram within the last two weeks. Similarly, disulfiram causes intolerance of ethanol. Cimetidine inhibits metronidazole metabolism, which may lead to an increase in its concentration in the serum and an increased risk dimethyl nandrolone undecanoate testosterone of side effects.
Co-administration of drugs that stimulate enzymes microsomal oxidation in the liver (phenobarbital, phenytoin), may accelerate the elimination of metronidazole in the resulting lowered concentration in plasma. Patients receiving long-term treatment of lithium therapy in high doses, when receiving metronidazole is possible to increase the concentration of lithium in the blood plasma, and the development of symptoms of intoxication.
The antimicrobial activity of metronidazole is enhanced in combination with sulphonamides and antibiotics.
In the combined reception metronidazole, and cyclosporine can be observed increase in the concentration of cyclosporine in blood plasma.
metronidazole reduces the clearance of fluorouracil, which can cause an increase in the toxicity of the latter.
with simultaneous use of metronidazole may increase plasma concentrations of busulfan.
it is not recommended to combine with nondepolarizing miorelaksaktami (vecuronium bromide).
With caution is prescribed for diseases dimethyl nandrolone undecanoate testosterone of the kidneys and liver.
In the period of treatment is contraindicated reception of ethanol (development disulfiramopodobnyh reactions: abdominal pain, spastic nature, nausea, vomiting, headache, sudden rush of blood to the face).
Long-term use of the drug, it is desirable to carry out under the supervision of peripheral blood .
At leucopenia the possibility of further treatment depends on the risk of infection.
The emergence of ataxia, dizziness and any other worsening of neurological status of patients required discontinuation of treatment.
It may immobilize treponema and lead to a false positive test Nelson. While receiving metronidazole may be a red-brown staining of urine.